In the first large-scale study of its kind, researchers from the Kobe University Graduate School of Medicine in Japan investigated the health effects of daily Omega-3 supplements in combination with a drug commonly prescribed for those at-risk for heart attacks, angina and other coronary events.

Patients were all identified as having higher than average levels of cholesterol. They were divided into two groups: a main group that included nearly 15,000 participants with no prior history of coronary artery disease, and a secondary group with over 3,600 subjects with a prior history of coronary artery disease. Some of each group were given highly-purified fish oil supplements in addition to statins (enzyme blockers that lower cholesterol levels in the blood by reducing the production of cholesterol by the liver), while others were given only the prescription drug.

Over the course of the nearly five-year study, there was a significant difference between those receiving the fish oil supplements and those who did not. While both therapies proved effective in reducing levels of cholesterol, participants taking the fish oil supplements and statins had a 19% reduction in risk for heart illness. The research also noted that a similar, preventative benefit from daily fish oil supplementation that may convey to those not currently deemed at-risk for heart problems.

“Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS).” American Heart Journal. 2003 Oct;146(4):613-20.

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